Near-Field Imprinting of Chiral Nanolayers by Plasmon-Induced Photopolymerization for Specific and Ultrasensitive Enantioselective Detection

The ability to discriminate between molecular enantiomers is crucial for applications in biology, medicine, and asymmetric synthesis. Here, we introduce a plasmon-induced near-field photopolymerization (NFPP) approach to fabricate molecularly imprinted polymer (MIP) nanolayers in situ onto gold-coated plastic optical fibers (POF@Au). Harnessing the intense electromagnetic confinement of surface plasmon resonance (SPR), this strategy enables nanometer-precise growth of chiral recognition layers d