De rol van lysosomaal ijzertransport in de ferroptosegevoeligheid van geneesmiddelresistente melanoomcellen

Ferroptosis is a recently discovered form of iron-dependent, genetically regulated, necrotic cell death driven by loss-of function of the lipid repair enzyme glutathione peroxidase 4 (GPX4), which results in accumulation of lipid hydroperoxides and cell death. Moreover, a new ferroptosis suppression pathway, governed by the ferroptosis suppressor protein 1 (FSP1), has been recently defined. Accumulating evidence suggests that this type of regulated necrotic cell death represents a cancer cell vu