Natural products provide great potential for contemporary medication development due to their diverse biological activity, large range of sources, and structural diversity. In this investigation, the enzymes collagenase, elastasei and hyaluronidase were inhibited by Clusiacyclol A, Cycloolivil, and Cyclopenol molecules with excellent to good IC50 values of 11.35 ± 1.24, 75.36 ± 11.73, and 25.17 ± 3.38 µM for Clusiacyclol A, and 19.42 ± 2.66, 84.16±6.80, and 94.36± 8.46 µM for Cycloolivil, and 0.