In present work, a heterogeneous Fenton process using prepared Fe2O3@ CeO2; 1:2 ratio /AC nanocatalyst was used to treat wastewater discharged from Iraqi petroleum refinery plant. The heterogeneous Fenton process was evaluated for its efficiency in removing COD via application a response surface methodology (RSM) and adopting a batch mode. Three essential operating factors were considered namely catalyst dosage (0.5-1.5 g/l), H2O2 dosage (0.4-1), and pH (3-7). The Fe2O3@ CeO2; 1:2 ratio /AC nano