This study aimed to evaluate the effects of ceramic composition, resin cement shade, and tooth-shaded background on the optical properties and color differences of high translucent (HT) lithium-based ceramics. A total of 192 specimens were prepared from four CAD/CAM ceramics: advanced lithium disilicate, lithium disilicate, and two zirconia-reinforced lithium silicate ceramics. The relative translucency parameter (RTP) and opalescence (OP) were evaluated using a digital spectrophotometer. Specim