Background Hypoglycemia is a common complication that is closely associated with poor prognosis in older patients with diabetes undergoing hemodialysis (HD). However, evidence regarding simple intradialytic preventive strategies remains limited. We evaluated the short-term effects of 15 g oral glucose solution on blood glucose levels and blood pressure. Methods This single-arm, self-controlled, pre-post pilot study included 12 older patients with diabetes undergoing HD between September and Octo