Abstract Background The present study compares the anti-plaque efficacy of two commercially available dentifrices containing natural salivary enzymes in patients undergoing fixed orthodontic therapy. Methodology This prospective, parallel- arm, double-blind, randomized controlled trial included 54 participants undergoing fixed orthodontic therapy who were diagnosed with moderate to severe gingivitis and were randomly allocated into three groups ( n = 18 per group). Group A received Dente 91 ® de