Introduction: Paediatric cancer is a leading cause of death in children and adolescents after common causes like malnutrition and infection. The field of paediatric oncology has developed significantly over the past few decades resulting in improved 5-year survival of all paediatric cancers to 75-80%. Objectives: To assess the clinical profile, short-term outcomes and survival of paediatric cancer patients treated at our state-run tertiary care cancer institute in Jabalpur, Madhya Pradesh, India. Method: This observational study was conducted for 2 years in the Paediatric Haemato-Oncology ward at State Cancer Institute, Jabalpur, Madhya Pradesh, India. After obtaining written informed consent, 234 children diagnosed with malignancies were enrolled in the study. Inclusion criteria were children aged 0 to <18 years diagnosed with malignancy. Data were recorded and entered in Excel sheet. Analysis was done focusing on the distribution of malignancies by age, gender and tumour type. All patients received chemotherapy, radiotherapy or surgery based on the type of malignancy. The study outcomes were categorized as remission, relapse or death. Results: Out of a total of 234 children, 152 (65 %) were males. Most common age of presentation was 0-5 years (39%). Common malignancies in decreasing order of frequency in our study population were leukaemia, lymphoma, renal tumours, soft tissue sarcoma, bone tumour, retinoblastoma, central nervous system tumours and germ cell tumours. Haematological malignancies constituted the highest frequency in our study population i.e., 154 (66%) children were diagnosed with leukaemia. Bone marrow transplant (BMT) was done in 3 children in our BMT unit. Fever (70%), pallor (44%), decreased appetite (60%), and bleeding spots (40%) were the common presenting symptoms. Outcome analysis indicated that 170 (72.6%) patients were alive at the end of the study, 25 (10.6%) had abandoned treatment and 24 (10.5%) had succumbed to the disease. The total number of relapsed cases was 15 (6.4%). Conclusions: Common malignancies were leukaemia, lymphoma, renal tumours, soft tissue sarcoma, bone tumour, retinoblastoma, central nervous system tumours and germ cell tumours. Haematological malignancies constituted 66% in our study population. Fever, pallor, decreased appetite, and bleeding spots were the common presenting symptoms. There were 10.5% deaths and 6.4% relapses.