Naunyn-Schmiedeberg s Archives of Pharmacology

Abstract Drug-induced gingival overgrowth (DIGO) is becoming an increasingly important issue due to high prescription rates of inducing pharmaceuticals. Therefore, the main focus of this study was to determine what experiences dentists in Germany have had with DIGO and which active ingredients cause this ADR in their patients. The conducted online survey was sent to all 17 German dental associati…

Abstract Melanoma is a highly aggressive cancer with limited therapeutic options. In melanoma cell lines, β 2 AR activation leads to the suppression of pro-proliferatory MAPK/ERK signaling. This suggests that fenoterol, a potent β 2 AR agonist, can be useful in the treatment of melanoma. Here, we investigated the structure–activity relationship (SAR) of fenoterol derivatives for β 2 AR-depedent E…

Abstract Hepatic ischemia–reperfusion injury is a major clinical problem associated with liver surgery, trauma, and transplantation, characterized by oxidative stress, inflammation, microcirculatory dysfunction, and apoptosis. Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to exert antioxidant, anti-inflammatory, and antiapoptotic effects. The present study aimed to inves…

Abstract Xylazine is an α2 adrenoceptor agonist approved for use in veterinary medicine as an analgesic and sedative. However, the recent use of xylazine as adulterant with opioids has created a public health emergency due to an increased number of addiction-related deaths and adverse effects. As a result, xylazine’s pharmacological profile has been revisited, and it has been found to act as a fu…