iScience

Summary Based on the success in pre-clinical models, methods that reduce sialylation in tumors have progressed to clinical trials, as this improves anti-tumor cellular responses. Immune responses against cancer can also be mediated by soluble, non-cellular mechanisms, such as the complement system. Dysregulation of the complement cascade and hypersialylation are hallmarks found across tumor types…

Strategic, competitiveness-driven, and protectionist trade measures are reshaping global trade, while climate commitments face mounting urgency. This evolving policy landscape requires renewed scrutiny of the trade-climate nexus, as governments depart from liberalization and adopt interventions that affect trade and production patterns. This perspective offers a framework that integrates fragment…

Spermatogonial stem cells sustain spermatogenesis within a Sertoli cell-organized niche, yet xenogeneic spermatogenic differentiation after transplantation into host mouse seminiferous tubules has been reported in only a limited number of donor species. Here, we tested whether host niche engineering could support xenogeneic spermatogenic differentiation. Immunodeficient mouse testes were precondi…

Diagnosing rare diseases remains a major challenge due to limited clinical knowledge and the frequent absence of diagnostic criteria. We present a digital framework that leverages large language models and biomedical text embeddings to bridge this gap. By mapping Human Phenotype Ontology terms to a shared vector space with millions of PubMed abstracts and full-text articles, our method enables ph…