Vaccine

Background Plasmodium vivax malaria is an increasing global health threat and the second leading cause of malaria globally. An efficacious vaccine aimed at preventing disease and transmission would greatly facilitate malaria elimination. The P. vivax circumsporozoite protein (PvCSP) is considered a leading pre-erythrocytic stage vaccine target. While P. falciparum malaria vaccines currently in cl…

Bacillus Calmette–Guérin (BCG) is employed to prevent tuberculosis (TB) during childhood. We reported the proteome of our vaccine candidate BCGΔBCG1419c and its parental BCG Pasteur ATCC 35734 strains, when cultured either as mature biofilms in Sauton medium or as planktonic cells in 7H9 OADC Tween 80 medium. Here, we perform in silico analyses aiming to determine: (1) proteins differentially pro…