neurodegeneration

Scientists at Baylor College of Medicine may have uncovered a promising new way to combat Alzheimer’s and Parkinson’s disease. Instead of trying to stop Tau and alpha-synuclein proteins from gathering into tiny droplets inside brain cells, the researchers found that tubulin—the protein that builds the cell’s internal transport network—can redirect these proteins away from forming toxic clumps and…

Source: Google News - Health If you're taking an omega-3 fish oil supplement to prevent Alzheimer's disease and dementia, take note: A new study has found these supplements do not improve memory, cognition, or brain cell loss. The study was a randomized, double-blind, placebo-controlled clinical trial—the gold standard of science—published in The Lancet journal ebioMedicine. What does work? Exerc…

A bump to the head can sometimes change a person’s life forever. Traumatic brain injury, often called TBI, happens when a sudden blow or jolt damages the brain. It can occur after a fall, a car crash, a sports injury, or another accident. Some brain injuries are mild and cause symptoms such as headaches, dizziness, […] The post A Surprising Link Between Brain Injuries and Brain Diseases in Older …

Background and objectivesThe diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is an important imaging biomarker for assessing glymphatic system function. However, the cortical and white matter metrics associated with changes in the DTI-ALPS index have not been fully elucidated, and the relationship between these two types of metrics remains controversial.MethodsWe com…

* Researchers at University Hospitals, Case Western Reserve University and the Cleveland VA identified a key molecular driver of age-related cognitive decline, offering a potential path toward the development of new treatments. * Published today in PNAS, the study pinpoints a key protein behind age-related breakdown of the blood-brain barrier (BBB), which leads to cognitive decline. * The researc…

Nature Communications, Published online: 19 June 2026; doi:10.1038/s41467-026-74576-x Little is known about how cerebellar population activity controls movements in ways distinct from individual neuron correlations. Here the authors show that Purkinje neuron population covariance uniquely influences motor coordination in mice.

Older mice that received a faecal microbiome transplant from younger animals went on to have improved brain plasticity, which suggests their brains could overcome a neurological condition that is typically successfully treated only in childhood

Alzheimer’s disease (AD) is the most common cause of dementia. Pleiotrophin (PTN) is a neurotrophic factor relevant for central nervous system repair, neuron differentiation and survival. It is upregulated in different neuroinflammatory conditions. PTN is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. In a previous study, we showed that a short treatment with the RPT…

A newly identified molecule called OLE helped restore the brain’s immune cells to a more protective state in Alzheimer’s models. The treatment reduced toxic plaque buildup and improved memory, raising hopes for a new therapeutic approach.

Background: Individuals with Down syndrome (DS) exhibit an almost complete penetrance of Alzheimer’s disease (AD) pathology but are underrepresented in clinical trials for AD. The Tau protein is associated with microtubule function in the neuron and is crucial for normal axonal transport. In several different neurodegenerative disorders, Tau misfolding leads to hyper-phosphorylation of Tau (p-Tau…

With every year, more evidence is connecting our eyes to Alzheimer's disease. The retina is...

Neurological disorders such as Alzheimer's disease, Parkinson's disease, and autism disrupt the brain's structural and functional organization, particularly in specific regions, and ultimately lead to cognitive impairments. In Alzheimer's disease-related dementia, neuronal degeneration impairs structural connectivity between brain regions, which in turn leads to functional breakdowns. This phenom…

The glymphatic system is a recently discovered brain waste clearance system that is mostly active during sleep and disengaged during wakefulness. Impaired glymphatic function leads to the deposition of metabolic waste products in the brain potentially causing inflammation leading to various symptoms in ME/CFS. While the glymphatic function has been assessed in other neurodegenerative diseases usi…

Researchers investigated whether modulating a deep brain region called the zona incerta (ZI) could alleviate persistent tremor in patients with Parkinson’s disease.

Nelson et al. present a detailed biomolecular study of how the APOE-R136S mutation protects against Alzheimer’s disease (AD) in mice and in patient-derived cells. Lots of data on glial contributions and transcriptomic changes. I see this as an excellent target for gene therapies aiming to combat AD. So do the folks at Lexeo Therapeutics (an […]

Traumatic brain injury, often called TBI, happens when a blow, bump, or sudden jolt to the head damages the brain. These injuries can range from mild concussions to severe brain damage that changes a person’s life forever. Every year, millions of people around the world experience traumatic brain injuries. Older adults are especially vulnerable because […] The post Brain Disorders and Head Injuri…

Disturbances in this critical sense are often linked to problems with brain health, researchers are learning

A USC study suggests that increasing omega-3 levels via supplements has little effect on brain health despite showing evidence that the nutrients directly reach the brain. The post Fish oil supplements may not prevent Alzheimer’s-related decline appeared first on USC .

A major study found that common dementia risks may have a much stronger impact on women’s brains than previously recognized. Women may not only experience some dementia risk factors more often than men, but those risk factors may also have a stronger effect on their cognitive health, according to new research from the University of [...]

The aging brain may be far more capable of growth and improvement than scientists once believed. A large three-year study from researchers at The University of Texas at Dallas’ Center for BrainHealth (CBH) is challenging a long-standing assumption about aging. The findings suggest that mental sharpness is not destined to decline over time and that [...]