neuropharmacology

Nature Communications, Published online: 22 June 2026; doi:10.1038/s41467-026-74553-4 Aggarwal et al. develop OCaMP, an orange fluorescent calcium indicator optimised for imaging neural activity at wavelengths above 1000 nm, enabling improved deep tissue imaging and expanded compatibility with existing sensors.

Inspired by the human brain, Oregon State University researchers have developed a new light-sensitive device that combines sensing and memory while controlling how digital memories strengthen or fade over time. The research was published in Advanced Functional Materials. Technology that functions more like the human brain could enable artificial intelligence systems to work faster while […]

Many of my essays are quite old. They were, in effect, written by a person who no longer exists in that my views, beliefs, and overall philosophy have grown and evolved over the years. Consequently, if I were to write on the same topics again, the resulting essays might differ significantly from their current versions. […]

IONA OS is an operating system written from scratch in Rust. It has its own kernel, its own GUI, its own blockchain protocol, its own programming language (Flux), and — since recently — its own kernel-integrated AI. Not a chatbot. Not a cloud API wrapper. An AI that runs in Ring 0, reads CPU temperature directly, kills processes, synthesises drivers, and optimises the system in real time. The har…

Nature Communications, Published online: 20 June 2026; doi:10.1038/s41467-026-74648-y Replicating the brain’s multisensory integration is vital for artificial intelligences. Liu et al. have developed biomimetic ferroelectric-semiconductor field-effect transistors to mimick the brain’s audiovisual integration driven by hardware-native multi-physics coupling.

Nature Neuroscience, Published online: 19 June 2026; doi:10.1038/s41593-026-02332-x Cao et al. identify tryptamine as a sleep signal in mice. Wake-active monoaminergic neurons release tryptamine, which binds to GPR139 in POA neurons that suppress wake-promoting neurons. GPR139 agonists could be a new class of sleep medication.

Researchers at the Medical University of Vienna, in collaboration with ETH Zurich, the Technical University of Munich and Medical Faculty Belgrade, have developed a wearable neurorobotic system that combines electrical neurostimulation with hand exoskeletons.

The human brain actively keeps "learning" in balance, by holding on to what matters and letting go of what does not. Researchers in Korea have now reproduced this ability in a semiconductor device, using the color of light to strengthen (remember) or weaken (forget) an artificial synapse's memory.

Pain affects over 30% of the global population, with an underlying pathogenesis involving a complex interplay of biopsychosocial factors. Despite the availability of conventional pharmacological and interventional therapies, their clinical utility is frequently constrained by concerns regarding substance misuse, surgical complications, and other adverse sequelae. Acoustic stimulation (AS) has eme…

IntroductionTraditional pharmaco-electroencephalography (EEG) studies have mainly examined the effects of psychotropic medications at the level of individual drugs or broad drug classes, limiting biological specificity and clinical translation. This study aimed to determine whether modeling EEG spectral power changes according to the engagement of distinct neurotransmitter systems provides a more…

Tiletamine is a dissociative anesthetic used in veterinary medicine and has recently emerged as a potential illicit additive in e-cigarettes after regulation of etomidate. However, reports of chronic tiletamine-containing e-cigarette use remain scarce. We report the case of a 22-year-old man who developed progressive gait instability, dysarthria, choking on drinking, hand tremor, emotional instab…

Nature Communications, Published online: 19 June 2026; doi:10.1038/s41467-026-74217-3 The authors find that dexmedetomidine reduces hyperactivity of lateral septum GABAergic neurons, alleviating pain and sleep disruption induced by spared nerve injury in male mice via the downstream circuits in the lateral preoptic area.

Researchers at Oregon State University have developed a new light-sensitive electronic device that works more like the human brain. The innovation could lead to artificial intelligence systems that process information faster while using much less electricity. The new device, described in the journal Advanced Functional Materials, combines three important functions into a single component: it […] …

IntroductionParkinson’s disease (PD) is the second most prevalent neurodegenerative disorder and is one of the leading causes of neurological disability. Although there are currently no cures or treatments for this disease, many patients with PD may therapeutically benefit from preventing or mitigating mitochondrial dysfunction. This study aimed to investigate the protective effects of paederosid…

BackgroundAntimicrobials are among the most frequently prescribed medications worldwide, yet their neurocognitive adverse effects remain underrecognized. The adverse effects range from mild symptoms to serious effects and unrecognized adverse effects may influence prescribing behaviors and inappropriate continuation or discontinuation of antimicrobial therapy. Evidence on healthcare providers’ aw…

This study analyzes neural and behavioral events occurring before, during, and after the emergence of a pain quale and the consciousness of that pain to examine the causal efficacy of the quale and consciousness. It finds that events occurring before or concurrently with the emergence of the quale are neither caused nor influenced by the quale or consciousness. Events occurring afterward may also…

Neuropsychopharmacology, Published online: 15 June 2026; doi:10.1038/s41386-026-02461-8 Phospholipase A2 downregulates inhibitory transmission in the amygdala and impairs fear extinction

Neuropsychopharmacology, Published online: 16 June 2026; doi:10.1038/s41386-026-02465-4 Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression

Neuropsychopharmacology, Published online: 17 June 2026; doi:10.1038/s41386-026-02467-2 Serotonin type 3 receptor (5-HT 3 R) antagonists for negative symptoms and cognitive impairment associated with schizophrenia: a systematic review and meta-analysis

From ultra-flexible materials redefining brain-computer interfaces (BCIs) to record-shattering global out-licensing deals, China’s biopharmaceutical sector is undergoing a profound qualitative transformation. ShanghaiEye takes you inside the Yunfan Future Factory and the cross-discipline innovation hub hosted by Chia Tai Tianqing (CTTQ)—a subsidiary of top-50 global pharma giant Sino Biopharmaceu…