Nature Medicine

Nature Medicine, Published online: 19 June 2026; doi:10.1038/s41591-026-04519-y Author Correction: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial

Nature Medicine, Published online: 17 June 2026; doi:10.1038/s41591-026-04457-9 Specialized clinical AI tools are entering medical practice with little independent testing. In a head-to-head evaluation across two public benchmarks and real questions from physicians, three general-purpose frontier large language models outperformed two leading clinical AI tools, which performed no better than Goog…

Nature Medicine, Published online: 17 June 2026; doi:10.1038/s41591-026-04473-9 CAR T cell therapy can induce deep responses but also severe toxicities in patients with smoldering myeloma, an asymptomatic cancer precursor; given the potential risks and benefits, its success depends on careful patient selection.

Nature Medicine, Published online: 17 June 2026; doi:10.1038/s41591-026-04499-z With its biomedicine at an inflection point, India can seize the opportunity to scale up research and development at home and offer a distinct model of biomedical innovation for the global south.

Nature Medicine, Published online: 17 June 2026; doi:10.1038/s41591-026-04474-8 In my view, we have never had as robust a body of evidence from observational data on an intervention for dementia as we do for live-attenuated shingles vaccination. Both a recent US National Institutes of Health expert workshop and an international expert consensus on Alzheimer’s disease drug repurposing identified l…

Nature Medicine, Published online: 16 June 2026; doi:10.1038/d41591-026-00031-5 Engineered heart muscle allografts derived from induced pluripotent stem cells show promising early outcomes in patients with treatment-refractory advanced heart failure with reduced left ventricular ejection fraction, in support of further clinical investigation.

Nature Medicine, Published online: 16 June 2026; doi:10.1038/s41591-026-04513-4 Author Correction: Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study

Nature Medicine, Published online: 15 June 2026; doi:10.1038/s41591-026-04414-6 An automated intracortical brain–computer interface, used at home with no researcher intervention, provides long-term and accurate restoration of speech-based communication and cursor-based computer usage in a person with severe dysarthria due to amyotrophic lateral sclerosis.

Nature Medicine, Published online: 15 June 2026; doi:10.1038/s41591-026-04446-y The biological age of individual cell types can be evaluated using plasma proteomics, revealing diverse aging profiles across more than 40 cell types and links between the accelerated aging of specific cell types and disease.

Nature Medicine, Published online: 15 June 2026; doi:10.1038/s41591-026-04432-4 Neural decoding algorithms that leverage physiological principles of locomotor encoding support activity-dependent deep brain stimulation therapies that improve locomotor deficits in people with Parkinson’s disease.

Nature Medicine, Published online: 15 June 2026; doi:10.1038/s41591-026-04434-2 A randomized crossover study shows that gait-phase-synchronized adaptive deep brain stimulation is feasible and safe, and reduces falls compared to continuous stimulation in Parkinson’s disease.

Nature Medicine, Published online: 15 June 2026; doi:10.1038/s41591-026-04447-x Blood signatures of cell type-specific aging forecast disease risk and resilience

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04421-7 The Hong Kong Genome Project established a genome sequencing database that provides improved diagnoses for patients and more efficient, population-tailored carrier status screening. Actionable pharmacogenomic variants were identified in almost all participants, informing drug prescriptions. This work establishes a gen…

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04465-9 Pramipexole, in patients with major depressive disorder, dysthymia or bipolar depression, reduced Snaith−Hamilton Pleasure Scale scores significantly compared to placebo.

Nature Medicine, Published online: 12 June 2026; doi:10.1038/s41591-026-04431-5 In an independent evaluation, frontier large language models outperformed specialized clinical artificial intelligence tools on medical knowledge, clinician alignment and real-world clinical queries.

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04409-3 We analyzed brains from octogenarians and cognitively resilient centenarians to understand why some individuals with substantial Alzheimer’s disease pathology develop dementia whereas others remain cognitively intact. Spatial transcriptomics revealed gene expression changes in discrete tissue domains surrounding amylo…

Nature Medicine, Published online: 11 June 2026; doi:10.1038/s41591-026-04510-7 Clinical Profile and Genomic Characterization of the 2026 Bundibugyo Virus Index Case in Uganda

Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04444-0 Announced in this Comment and in collaboration with Nature Medicine is the convening of the Brain Health for Economic Resilience Commission, a global, transdisciplinary effort to define, measure and operationalize brain health and cognitive capacity as foundational drivers of economic resilience.

Nature Medicine, Published online: 10 June 2026; doi:10.1038/s41591-026-04436-0 Phase 1 results reveal that BBM-P002, a dual-target gene therapy co-delivering TH and DDC, is safe and well tolerated in Parkinson’s disease, with 12-month motor improvements signaling therapeutic potential.

Nature Medicine, Published online: 09 June 2026; doi:10.1038/s41591-026-04429-z An interim report of a first-in-human phase 1 trial found an adjuvanted, combination inactivated rabies-vectored, Lassa fever vaccine (LASSARAB + 3D-6-acyl PHAD-SE) to be safe and induced immunogenicity to both Lassa and rabies viruses in healthy participants.