PROTAC-Splitter: a machine learning framework for automated identification of PROTAC substructures

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules composed of an E3 ligase ligand, a linker, and a warhead targeting a protein of interest. Despite their modular structure, accurately identifying and annotating these components in PROTACs is challenging and typically relies on manual curation and predefined substructure matching. To address this, we developed PROTAC-Splitter, a machine learning framework designed for automated annotation of PROTAC substructures. To addres