ABSTRACT This review is an update of our previous contribution published in Angewandte Chemie in January 2019 and provides a critical analysis of the overall scientific production and key findings from NMR‐based metabolomics between January 2018 and April 2025. We developed a strategy (described in the Methodological Approach section) for systematically analyzing the literature that enabled us to identify 5081 studies published during this observation period. Descriptive statistics were used to