Synthesis, in silico, and biological evaluation of new schiff base derivatives as antibacterial and anti-breast cancer agents

Three new Schiff base compounds (S1-S3) from 1-([1,1'-biphenyl]-4-yl)ethan-1-amine and substituted-benzaldehydes are synthesized and biologically evaluated in this work. After microwave-assisted synthesis, the compounds were purified and structurally characterized by FTIR, 1H-NMR, and 13C-NMR. Agar diffusion was used to test their antibacterial activities against pathogens such Staphylococcus aureus, Escherichia coli, Bacillus anthracis, and Acinetobacter. The derivative S2 was the most antibact