organic-chemistry

Nature Communications, Published online: 22 June 2026; doi:10.1038/s41467-026-74592-x The development of catalytic systems for the enantioselective epoxidation of sterically hindered trisubstituted alkenes and the oxidation of sulfilimines to sulfoximines using molecular oxygen (O₂) as the terminal oxidant remains a formidable challenge. Here, the authors report a biomimetic bifunctional photocat…

Whats all this about? If you told me from the start that in order to make an actually viable IUPAC naming python library, I would have to read pages upon pages of the a dense, chemistry-jargon filled document called the Blue Book , I would have screamed. However, nothing ventured nothing gained, and while I'm sure there is a library for this somewhere out there, wheres the fun in that? While I ha…

A mysterious light-absorbing substance on Titan and Pluto could reveal hidden chemical processes and prebiotic pathways in the outer solar system.

Scientific Reports, Published online: 21 June 2026; doi:10.1038/s41598-026-58103-y Prediction of physicochemical properties of organic compounds using degree-based topological indices and machine learning models

Nature Communications, Published online: 21 June 2026; doi:10.1038/s41467-026-74673-x Glutarimide-containing CRBN ligands are central to targeted protein degradation but remain synthetically challenging. Here, the authors report a unified organocatalytic platform enabling rapid, selective, and scalable assembly of diverse glutarimides, facilitating library synthesis and late-stage functionalisati…

Nature Astronomy, Published online: 19 June 2026; doi:10.1038/s41550-026-02877-8 The returned samples from asteroids Bennu and Ryugu document a remarkably rich organic inventory, spanning from smaller molecules to complex macromolecular materials. This chemical diversity renews the discussion of how prebiotic complexity on small bodies may relate to the processes leading to the emergence of life.

Nature Communications, Published online: 20 June 2026; doi:10.1038/s41467-026-74668-8 Acyclic Schiff base atropisomers have remained inaccessible because of longstanding synthetic and stereocontrol challenges. Here, the authors report a palladium-catalysed asymmetric N-allylation enabled by substrate guided catalyst evolution, delivering Z selective atropisomeric Schiff bases with high yields and…

Nature Communications, Published online: 20 June 2026; doi:10.1038/s41467-026-74660-2 The authors report a practical and divergent electrochemical method for converting simple secondary amines into thiocarbamoyl fluorides and N-trifluoromethyl amines, proceeding under mild, open-air conditions without solvent drying, degassing, inert atmosphere, or stoichiometric silver reagents.

Nature Communications, Published online: 20 June 2026; doi:10.1038/s41467-026-74595-8 The authors report a regioselective hydrogen atom transfer process that enables divergent carbamoylation of branched alkenes. Through modulation of the electronic and steric properties of the ligands, this cobalt complex achieves precise discrimination between hydrogen atoms exhibiting minor differences in bond …

Nature Chemistry, Published online: 18 June 2026; doi:10.1038/s41557-026-02180-z Controlling stacking sequences in van der Waals materials to tune their physical properties is challenging. Now a solvent-directed strategy enables programmable stacking control and divergent charge transport regimes in two-dimensional and three-dimensional conducting van der Waals metal–organic frameworks.

Profs. Brent Sumerlin and Matthew Eddy have been elected into the Academy of Science, Engineering & Medicine of Florida (ASEMFL). The post Two UF Chemistry Faculty to be Inducted into the ASEMFL appeared first on Chemistry .

Nature Communications, Published online: 18 June 2026; doi:10.1038/s41467-026-74187-6 The authors present a copper-catalyzed dynamic kinetic asymmetric allylation of racemic α,β,β-triarylethanones, providing efficient access to a diverse range of chiral α,β,β-triaryl tertiary alcohols with robust enantioselectivity and diastereoselectivity.

Nature Communications, Published online: 18 June 2026; doi:10.1038/s41467-026-73870-y Chiral helicenes are valuable across disciplines, yet strategies to construct helical chirality—particularly in polychiral or heteroatom containing systems—remain limited by limited substrates and challenging stereochemical control. Here, the authors report an enantioselective dynamic kinetic resolution enabling…

Nature Communications, Published online: 18 June 2026; doi:10.1038/s41467-026-74600-0 Authors present an ErCl₃-catalyzed cyanation of both aliphatic and aryl ketone hydrazones for the facile access of C(alpha)-tetrasubstituted alpha-hydrazino nitriles in up to 96% ee, by using a sterically confined pyridinebisoxazoline (PYBOX) ligand featuring a sulfonyl group at the pyridine C4 position.

For more than a hundred years, chemists have been building complex molecules step by step – bond by bond, atom by atom. But what if, instead of painstakingly reassembling molecules, they could be directly "rewritten"? This is exactly what a research team led by organic chemist Nuno Maulide from the ...

Please note that, per MAPS scheduling notices, presenters at the Fall 2026 ACS National Meeting in Chicago, IL must register by today, June 15, 2026, otherwise your abstract will be considered withdrawn. Thank you to INOR division for publicizing this! The post Presenter registration deadline today for Fall 2026 ACS National Meeting appeared first on ACS Division of Organic Chemistry .

Nature Chemistry, Published online: 15 June 2026; doi:10.1038/s41557-026-02178-7 The selective functionalization of unprotected amines with alkenes remains a challenge in contemporary synthesis. Now a strategy has been developed for an alkyl swap of N-methylamines, enabling late-stage bioconjugation and peptide modification. The resulting retrosynthetic disconnection also streamlines the preparat…

Nature Communications, Published online: 15 June 2026; doi:10.1038/s41467-026-74546-3 The authors report an N-heterocyclic carbene-catalyzed radical Smiles-type rearrangement which selectively produces 1,4-difunctionalized arenes.

Nature Communications, Published online: 15 June 2026; doi:10.1038/s41467-026-74317-0 1,n-Difunctionalized alkyl linchpins are valuable synthetic intermediates, but current routes suffer from poor step economy and limited functional group tolerance. Here, the authors report a radical-mediated bidirectional C–C bond cleavage strategy that transforms cyclic ketones into diverse functionalized linch…