Predictive role of immune cell subsets and intestinal flora in immune-related adverse event of small cell lung cancer.

8112 Background: While immune checkpoint inhibitors (ICIs) have reshaped the therapeutic landscape for extensive-stage small-cell lung cancer (ES-SCLC), they are frequently associated with immune-related adverse events (irAEs) that may lead to treatment disruption. Early prediction of irAEs remains challenging due to their atypical clinical manifestations. This study aimed to identify risk factors and predictive biomarkers for irAEs in ES-SCLC patients undergoing ICIs therapy. Methods: 88 patien