Time-restricted eating versus calorie restriction for improving biomarkers of age in adults with overweight or obesity and incipient fatty liver disease: protocol for the ENSATI randomized controlled parallel groups trial

Introduction The increasing global lifespan has shifted the primary objective of geroscience from merely extending lifespan to maximizing health span. Biological aging is a gradual, time-dependent process marked by progressive cellular deterioration that culminates in increased vulnerability, frailty, morbidity, and mortality. Understanding the mechanisms that accelerate or decelerate this deterioration is crucial for developing effective interventions. Diet is recognized as the leading modifiab