physiology
A marathon, 100 kilometers or even 230 kilometers in one go: Anyone running such distances puts enormous strain on their body.
An hour in 14°C water sharply raised catecholamines in blood, but the experiment did not measure brain dopamine, euphoria or a two-hour post-plunge effect.
Scientific Data, Published online: 02 September 2026; doi:10.1038/s41597-026-08156-5 A multimodal gait dataset with ultrasound, EMG, and motion capture from young adults at various walking speeds

No matter where you’re from, there are things you can do to cope better with extreme temperatures. But it takes work to stop our bodies’ adaptations from slipping backwards over winter, and there are limits to how far we can go

The extent of walking impairment varies among individuals with peripheral artery disease (PAD), which may reflect differences in the adaptability of lower extremity muscles to ischemia-reperfusion injury characteristic of the disease. Analyses of gastrocnemius muscle biopsies from 113 individuals with PAD [mean ankle-brachial index (ABI) = 0.65 ± 0.13, 38 (33.6%) women, 76 (67.2%) Black] showed a…

The heart is a dynamic pump whose function is influenced by its mechanical properties. The viscoelastic properties of the heart, i.e., its ability to exhibit both elastic and viscous characteristics upon deformation, influence cardiac function. Viscoelastic properties change during heart failure (HF), but direct measurements of failing and non-failing myocardial tissue stress relaxation under con…

A new study identifies possible mechanisms behind changes in astronauts' lower eyelids, a symptom associated with long periods in space that can affect their eyesight.

Two-pore-domain K + channels (K2p), known previously as leak channels, are responsible for maintaining the resting membrane potential of cells. Fifteen subtypes are known to exist in humans and eleven are known in Drosophila melanogaster, as well as six subfamilies; however, little is known about the expression of these subtypes in various animal tissues or the impact of altered expression on cel…
The purpose of perspiration was a mystery in 1775, when English physician Charles Brian Blagden and a few inquisitive friends experimented on themselves by spending time in rooms heated to over 230° Fahrenheit.
Scientists have discovered that a key molecule released during exercise strengthens muscles, improves exercise performance and could be a therapeutic treatment for muscle damage caused by type 2 diabetes.
Just a few minutes of very hard exercise may trigger surprisingly large changes throughout the body. New research from Rockefeller University found that short bursts of all-out sprinting changed hundreds of substances circulating in the blood almost immediately. The response was much larger than researchers saw after far longer sessions of moderate exercise. Six 30-second […] The post Three Minut…
BackgroundChronic ankle instability (CAI) is a common sequela of lateral ankle sprain and is associated with recurrent injury, persistent functional limitations, sensorimotor deficits, and impaired postural control. However, how individuals with CAI adapt to graded and combined sensory feedback disruption remains unclear. This study aimed to determine whether individuals with CAI exhibit altered …
Scientific Reports, Published online: 10 August 2026; doi:10.1038/s41598-026-66004-3 Layer-specific stiffness dynamics in supraspinatus and trapezius muscles during a sustained isometric contraction
Platelet-rich plasma (PRP) exhibits substantial inter-individual variability, yet the physiological factors influencing its composition remain poorly defined. Most studies evaluate PRP as a homogeneous product, potentially masking associations between donor-related characteristics and platelet parameters. This study aimed to determine how key physiological factors influence whole blood (WB) and P…
IntroductionObjective assessment of hindlimb skeletal muscles in dogs remains challenging in small animal practice. This study aimed to use computed tomography (CT) to characterize hindlimb muscle distribution, identify optimal measurement levels, and evaluate the clinical applicability of a palpation-based hindlimb muscle condition score (hMCS) system.MethodsThis prospective observational study …
A newly published Finnish study demonstrates that, in addition to temperature, air humidity is a significant determinant of physiological strain during sauna bathing.
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