Camurati-Engelmann Disease: A Narrative Review of Clinical Features, Molecular Pathogenesis, Diagnosis, and Emerging Targeted Therapies

Camurati-Engelmann Disease (CED) is a very rare, autosomal-dominant type sclerosing bone dysplasia that is characterised by progressive diaphyseal hyperostosis, cortical thickening of long bones, along with variable involvement of skull-base. This narrative review synthesises the current evidence regarding clinical features, molecular basis, diagnosis, as well as management strategies of CED. Clinically, patients having CED, usually present in childhood or adolescence age with chronic pain in li