Discoveries of skull-associated immunity and skull-meningeal vascular channels have changed how neuroimmune trafficking is understood. These channels connect calvarial marrow and meningeal or brain-border compartments, and calvarial marrow can serve as a local myeloid reservoir for central nervous system (CNS) inflammation [1][2][3] . Intracalvarial or intracalvariosseous delivery has therefore attracted interest as a potential route for CNS drug delivery in stroke 4,5 .Intracalvarial or intraca