Quality of life and its influencing factors in patients with neuromyelitis optica spectrum disorder

Background Neuromyelitis optica spectrum disorder (NMOSD) imposes a significant burden on health-related quality of life (HRQoL). However, comprehensive studies examining HRQoL and its biopsychosocial determinants in Chinese NMOSD patients remain scarce. Methods In this cross-sectional study, 216 Chinese patients with NMOSD underwent clinical evaluation for neurological disability (EDSS) and completed a battery of standardized self-report measures. These scales assessed HRQoL (SF-36), basic acti