Didymin mitigates neuroinflammation and preserves blood–brain barrier integrity after subarachnoid hemorrhage

Objective Subarachnoid hemorrhage (SAH) is a highly lethal and disabling type of stroke. The main causes of poor prognosis are neuroinflammation, blood–brain barrier (BBB) disruption and brain edema following hemorrhage. Didymin has shown neuroprotective effects in intracerebral hemorrhage; however, its regulatory role in SAH remains unclear. Methods The rat SAH model was established using the internal carotid artery puncture method, while an in vitro model was developed by stimulating human bra