Abstract Plasmodium falciparum possesses one of the most AT-rich genomes in nature (80.6%). A consequence is an asparagine-rich proteome. A quarter of P. falciparum proteins possess poly-asparagine repeats that can extend more than 100 residues. The role of these repeats has remained a mystery in the biology of this parasite. Here, we report that the poly-asparagine repeat-containing Nterminus of the histone acetyltransferase PfGCN5 associates with the C-terminal catalytic domain after cleavage