Proteolytic Colonic Microbiota Is Associated with Increased Clinical and Endoscopic Disease Activity in Ulcerative Colitis Running head : Microbiota and disease activity in ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with an increasing burden in Asia. Although gut microbiota alterations have been widely reported in UC, evidence linking microbiota patterns with both clinical and endoscopic disease activity remains limited, particularly in Indonesian populations. This study aimed to evaluate the association between colonic microbiota patterns and clinical and endoscopic disease activity in patients with UC. This cross-sectional study was conducted