Version 2.1 of the Quarantine Capsule Hypothesis. This standalone framework proposes that solid tumors emerge within host-built fibrotic containment capsules formed around persistent unresolved danger. This version introduces the Defeat Signal Principle (DSP), Toxic Containment Principle (TCP), Collapse Density Index (CDI), and Eternal Prison Principle (EPP), alongside the established Fibrotic Primacy, Evolution Chamber, and Hijacking Principles. Ten principles. Ten testable predictions.