Scientific Reports

Abstract Cancer is a disease characterized by genomic instability and aberrant DNA repair. Poly (ADP-ribose) polymerase-1 (PARP-1) represents a well-established therapeutic target, particularly in ovarian and prostate cancer. However, the currently approved PARP inhibitors face challenges such as resistance, toxicity, and reduced efficacy. The search for alternative scaffolds has therefore become…

Distance-based selection has been the conventional criterion for weather file selections, although this topographically- and meteorologically-agnostic decision may lead to unreliable Climate-Based Daylight Modelling (CBDM) simulation results. To mitigate this risk, this study explores alternative criteria that may be better predictors of weather file proxies for locations within the tropical clim…

Abstract Thrombocytopenia is a common hematological disorder with diverse etiologies. This study aimed to identify potential biomarkers and to develop an interpretable diagnostic nomogram for the early recognition of hypo-productive thrombocytopenia. This retrospective study included 185 patients with thrombocytopenia who were admitted to the Department of Hematology at the Affiliated Suzhou Hosp…

Abstract Intercropping has emerged as a promising strategy to improve agroecosystem biodiversity and mitigate some adverse effects associated with intensive monoculture systems. This study evaluated weed infestation and biodiversity responses in a Paulownia –buckwheat intercropping system compared with buckwheat monoculture under the environmental conditions of southwestern Poland. Weed species c…

Deformed Wing Virus type A (DWV-A) is one of the primary threats to honeybees ( Apis mellifera ), significantly impacting their nervous system physiology and behavior. While its neurotropic nature is well-recognized, the temporal dynamics of the neuronal transcriptomic response following oral infection, the natural transmission route, remains poorly understood. In this study, we analyzed gene exp…

Dermal adipocytes have emerged as active participants in cutaneous host defense. In parallel, adipocyte hypertrophy and hyperplasia–driven obesity has become a global public health priority and is strongly associated with increased risk and severity of bacterial infections. Here, we established and optimized two complementary S. aureus infection models—epidermal and subcutaneous—and in combinatio…

Abstract We propose a leakage-free wavelet-based methodology for drought prediction that enables both competitive forecasting performance and improved interpretability of predictor–target relationships. Unlike standard time-series decomposition approaches, the wavelet transform is applied within moving windows of the past values, preventing the use of future information during model training. The…

Mud-dominated reservoirs exhibit significant heterogeneity driven by depositional processes and post-depositional modification, yet the role of micro-scale bioturbation remains poorly constrained. This study focuses on the impact of diminutive trace fossils ( Multina and Phycosiphon ) within event beds of the Lower Silurian Qusaiba Member (Qalibah Formation, Saudi Arabia) using micro-computed tom…

Cervical cancer substantially impairs HRQoL, particularly among women in socially and economically productive age groups. EQ-5D utility values are important inputs for quality-adjusted life-year estimation, cost–utility analysis, and health technology assessment; however, pooled EQ-5D estimates for cervical cancer remain limited. This PRISMA 2020-compliant systematic review and meta-analysis sear…

We report a scalable fabrication strategy for flexible piezoelectric nanofiber transducers through a single-nozzle, self-assembling electrospinning process. Unlike traditional coaxial methods, this approach exploits the surface energy differential between polyvinylidene fluoride (PVDF) and multi-walled carbon nanotubes (MWCNTs) to drive the spontaneous formation of a core-shell architecture. The …