Polycystic ovary syndrome (PCOS) is an endocrine disorder leading to varied health complications, such as high blood pressure, Type 2 diabetes, infertility, and depression among women in the United States. Most studies have focused on managing the physical aspects of PCOS. Limited research to date has been conducted to determine the intrinsic and extrinsic motivation women living with PCOS harness to navigate the physical, psychosocial, and access to care in New Jersey, which are contributors to positive social change. This basic qualitative study utilized semistructured open-ended questions to determine the experiences and perspectives of women between the ages of 18 to 49 years, focusing on their intrinsic and extrinsic motivational factors contributing to self-efficacy. The research questions focused on the motivational factors that contributed to health-seeking behaviors for the self-management of PCOS. This study utilized reflexive thematic analysis, within the framework of the health belief model and self-determination theory, to explore the unique motivational factors women employed that led to health-seeking behaviors for the self-management of PCOS. The major themes that arose from this study showed women utilized motivation to understand their unique PCOS symptoms; addressed family, social, health system challenges; and were active participants in their own adaptive learning to create dynamic PCOS-centered personalized healthcare teams. The inclusion of these findings is a basis for future health educational programs. The social change implication is that these findings can help health professionals and health educators to develop educational programs and resources based on addressing the motivational factors identified by women living with PCOS.