medicine

How often do people in high-burden areas get malaria? Studies suggest that many children can experience five or more malaria infections a year.

Insilico Medicine ("Insilico"), a clinical-stage company focused on generative AI-driven drug discovery and development, today announced the publication of a new study conducted in collaboration with an international team of scientists from Harvard Medical School, Stanford University, The Broad Institute, RWTH Aachen University, Peking University and Westlake University.

Artificial womb technology is approaching over the scientific horizon. Recent proof-of-principle experiments using foetal animals have prompted a new surge of bioethical interest in the topic: scholars have asked what ectogenesis would mean for individuals, family, oppressed groups, and society at large; how we can or should regulate the technology; and whose interests motivate ectogenic research…

Nature Reviews Drug Discovery, Published online: 07 September 2026; doi:10.1038/s41573-026-01514-3 There are currently no approved therapies for sarcopenia, the age-related loss of skeletal muscle mass and strength. This Review discusses advances in understanding of the cellular, molecular and metabolic mechanisms driving muscle wasting with ageing, while assessing emerging therapeutic approaches…

A new study in mice and patients shows that atherosclerosis meets the criteria for an autoimmune disease.

Patients' responses to questions routinely raised by oncologists may provide important clues about their chances of survival from chronic lymphocytic leukemia (CLL), according to a new study published in the journal Therapeutic Advances in Hematology.

Nature Communications, Published online: 07 September 2026; doi:10.1038/s41467-026-76570-9 T cell proliferative capacity and persistence are key determinants of CAR-T cell therapeutic efficacy. Here, the authors show that CAREp, a microparticle-based platform displaying CAR-targeting antigens and CD28-costimulatory antibodies, selectively and sustainably expands human CD8+ CAR-T cells while maint…

IntroductionMolecular hybridization is an effective approach employed to synthesize molecules that possess the ability to function as dual inhibitors, thereby addressing the issue of growing resistance. Resistance by the malaria parasite is one such example. Therefore, the study aims to develop hybrid compounds consisting of 4-aminoquinoline and 4-thiazolidinone, utilizing molecular docking for s…

The complexity of data pertaining to patients diagnosed with cancer requires a shift from fragmented, unimodal diagnostics towards multimodal artificial intelligence (MAI) in order to achieve true precision oncology. In this literature review we examined the landscape of unimodal data modalities used in oncological practice including clinical records, multi-scale imaging (radiology and histopatho…

Clinically useful artificial intelligence and machine-learning studies in healthcare require interpretable features, internal validation, and explicit boundaries between primary inference and external context. Among 1,612 baseline Parkinson’s Progression Markers Initiative (PPMI) participants, 1,439 had evaluable post-baseline cognition and contributed 5,909 records through Year 5. Composite cogn…

Researchers at Asfendiyarov Kazakh National Medical University (KazNMU) have identified biologically active compounds with antiviral, antimicrobial, and anti-inflammatory effects in several plant species native to Kazakhstan, providing new chemical and experimental data on medicinal flora from Central Asia.

BackgroundCoagulopathy is a common risk factor in the occurrence of intraventricular hemorrhage (IVH) and subsequent poor neurological outcomes in preterm infants. The causal effect of fresh-frozen plasma (FFP) transfusion and IVH needed to be identified urgently.MethodsWithin the framework of target trial emulation (TTE), we mimic the process of a randomized controlled trial based on retrospecti…

BackgroundPrimary brainstem hemorrhage (PBH) is a severe, poorly-prognostic stroke subtype. Since single biomarkers cannot reflect global inflammatory status, we constructed a composite Inflammatory Burden Index (IBI) incorporating neutrophil-to-lymphocyte ratio (NLR), C-reactive protein-to-albumin ratio (CAR), and systemic immune-inflammation index (SII), and assessed its links with 90-day poor …

The hard part of comparing a high-deductible, low-premium plan with a low-deductible plan is not adding two premiums. Medical spending varies, and a fair comparison should expose both ordinary and expensive years. I built this simulator so both plans see the same generated spending path; otherwise random noise can make one plan look better simply because it received easier years. The useful audie…

You sit down and put your arm in the cradle. You press a button. The machine takes it from there. A near-infrared light sweeps your inner elbow, hunting for a vein. A puff of alcohol hits your skin. An ultrasound probe glides across the arm, mapping how deep the vessel runs and which way it bends. Doppler captures the direction of blood flow to rule out the artery. The cuff tightens around your u…

Renal anemia is one of the most common complications of chronic kidney disease (CKD). This study investigated gut microbiota composition and fecal/plasma short-chain fatty acids (SCFAs) in 30 non-dialysis renal anemia patients and 20 healthy controls. Gut microbiota was assessed by 16S rRNA gene amplification sequencing and SCFAs were measured using gas chromatography-tandem mass spectrometry (GC…

BackgroundPatients with depression exhibit significant gut microbiota dysbiosis; however, visualized studies into dysbiosis-related microbial signatures in depression remain limited. To identify characteristic differential genera in depressed individuals, this study adopted a knowledge graph–based visualization analysis to clarify the associations between intestinal microbial dysbiosis and depres…

Major depressive disorder (MDD) remains challenging to treat due to the lack of objective biomarkers for monitoring treatment response and predicting outcomes. Traditional treatment response evaluation rely heavily on subjective assessments, creating a pressing need for objective biomarkers to monitor therapeutic efficacy. Functional near-infrared spectroscopy (fNIRS), a non-invasive, portable, a…

Novo Nordisk has stopped two trials of a drug that aims to tame inflammation as a way to improve cardiovascular health, another blow for the approach.