ObjectiveThis study aimed to reveal the profiles of the flourishing in undergoing maintenance hemodialysis (MHD) and to investigate influencing factors guided by the principles of Social Support Resource Theory.MethodsA total of 376 MHD patients were recruited between October and November 2022. The study used the PERMA Profiler of Chinese Version, Regulatory Emotional Self-Efficacy Scale, Perceived Social Support Scale, and Simplified Coping Style Questionnaire for data collection. Latent Profil