IntroductionLocal anesthetic systemic toxicity (LAST) causes significant ventricular repolarization disturbances. While intravenous lipid emulsion (ILE) is the standard treatment, the factors governing the simultaneous recovery of electrical and mechanical functions remain unclear. We evaluated ILE efficacy in reversing repolarization alterations and hemodynamic collapse induced by clinically equipotent doses of bupivacaine and ropivacaine.MethodsTwelve swine were randomized to receive a toxic b
Differential recovery of ventricular repolarization and hemodynamics following bupivacaine and ropivacaine intoxication: the impact of lipophilicity on lipid emulsion efficacy
Matilde Zaballos
