Nature Communications, Published online: 18 June 2026; doi:10.1038/s41467-026-73870-y Chiral helicenes are valuable across disciplines, yet strategies to construct helical chirality—particularly in polychiral or heteroatom containing systems—remain limited by limited substrates and challenging stereochemical control. Here, the authors report an enantioselective dynamic kinetic resolution enabling efficient construction of polychiral helical architectures.