This case study describes the development and implementation of an interactive game of a 30-L bioreactor system in both computer and virtual reality (VR)-based versions from two angles: (1) development and integration of an interactive virtual bioreactor game system in the form of a 360-degree computer game and an immersive VR bioreactor game for a biomanufacturing laboratory course, and (2) exploratory adoption of the VR bioreactor into an environmental engineering laboratory course with an ass