Tomasi, David: The Role of Monoamine Transporters SLC6A3 and SLC6A4 in Early Brain Maturation

Proceedings of the National Academy of Sciences (LXI). 2026Monoamine transporters are critical regulators of neurotransmission during early brain development. The dopamine transporter (DAT), encoded by SLC6A3, and the serotonin transporter (SERT), encoded by SLC6A4, modulate extracellular monoamine levels via sodium-and chloride-dependent reuptake. This study integrates developmental neuroscience literature with secondary functional neuroimaging analysis of the OpenNeuro dataset (ds001420) to