Nature Communications, Published online: 22 June 2026; doi:10.1038/s41467-026-74658-w Antibodies that target the stem region of the influenza haemagglutinin are sought because this region is conserved between different clades and subtypes of the virus. Here, the authors characterize three stem reactive human antibodies and show functional neutralization and binding specificity, showing differences in binding site as well as Fc-dependent effector function.