Nature Communications, Published online: 22 June 2026; doi:10.1038/s41467-026-74677-7 Rice root-knot nematode (RRKN) is one of the most destructive pathogenic nematodes threatening rice production worldwide. Here, the authors report the identification of RRKN susceptibility factor 1 (Rsf1) and show its usefulness in enhancing RRKN resistance without impacting yield in field conditions.