AIM: To examine differences in IgG N-glycan composition between physical activity (PA) categories and to assess associations between PA domains and IgG N-glycan traits in medical students. METHODS: This cross-sectional study enrolled first-year and second-year medical students at the University Josip Juraj Strossmayer, Osijek. PA was assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), capturing walking, moderate, and vigorous PA, total PA, and sitting time. Par