PubMed

Polymeric composite membranes are essential in modern separation technologies but pose critical challenges for sustainable end-of-life (EOL) management due to their chemically heterogeneous, multilayer structures. Existing approaches, such as mechanical processing or catalytic depolymerization, exhibit limited efficiency in separating and recovering multiple components. Here, we present a stage-b…

ions through the dislocation line.

, we examined how aggregation and heterogeneity shape the exploration-vigilance trade-off under predator-like looming stimuli. A latent negative relationship between exploration and vigilance became apparent when aggregated, suggesting improved behavioral performance compared to solitary condition. Heterogeneity within the group further enhanced performance beyond expected levels, indicating an a…

under varied illumination angles, wavelength, substrate composition, bacterial seeding, and index matching conditions. Combining experiments with ray-tracing simulations, we show that scattering arises from two interacting components: volume scattering within the body and surface scattering at interfaces between the worm and its surroundings. Surface scattering dominates at low angles and enhance…

T cell profiles reflect the magnitude of cellular immune responses, potentially affecting disease severity.

. Moreover, OV-BiTE treatment also markedly enhanced CAR T cell infiltration and tumor cytotoxicity in a GBM-BBB spheroid model, possibly through downregulation of endothelial junction protein expression. We then showed that intratumoral injection of OV-BiTE followed by infusion of combined EGFR and EGFRvIII CAR T cells was more effective than OV-BiTE supplemented with either CAR T therapy alone …

AIM: To determine the diagnostic yield of comprehensive genetic testing in patients with neuroimaging findings suggestive of lissencephaly spectrum disorders and to characterize novel pathogenic variants contributing to the genetic architecture of the spectrum. METHODS: We reviewed clinical and genetic findings of 23 patients with neuroimaging features suspected of the lissencephaly spectrum who …

Advances in forensic genomics, which include massively parallel sequencing, dense single nucleotide polymorphism testing, and forensic genetic genealogy (FGG), have greatly expanded the range of cases in which DNA evidence can generate investigative leads. As a result, the primary limitations in modern forensic DNA analysis are no longer analytical sensitivity or marker availability, but the abil…

Chronic systemic inflammation is a key driver of disease progression in rheumatoid arthritis and chronic kidney disease (CKD), particularly in patients undergoing long-term hemodialysis. Persistent elevation of proinflammatory cytokines contributes to pain, anemia, endothelial dysfunction, and increased cardiovascular risk, while therapeutic options are often limited by comorbidities and drug int…

AIM: To examine differences in IgG N-glycan composition between physical activity (PA) categories and to assess associations between PA domains and IgG N-glycan traits in medical students. METHODS: This cross-sectional study enrolled first-year and second-year medical students at the University Josip Juraj Strossmayer, Osijek. PA was assessed using the International Physical Activity Questionnair…

This case report presents an updated interpretation of genetic and chronological data from human remains discovered in Bezdanjača Cave, a Bronze Age burial site located in the Lika region of Croatia. The cave contains a complex necropolis with at least 57 graves and up to 200 individuals, which indicates its use as a collective burial site during the Middle and Late Bronze Age. Based on ancient D…

AIM: To present a five-criterion calibration framework for evaluating artificial intelligence (AI) tools in pathology centered on preserving "brain capital" - the finite cognitive resources available to clinicians - and stabilizing the "diagnostic apex," the point where histological evidence meets clinical judgment. METHODS: Using cognitive load theory (CLT) and implementation science, we develop…

AIM: To investigate integrated biochemical and glycomic signatures in humans related to coordinated metabolic and endocrine adaptations during prolonged fasting, which are essential for maintaining systemic homeostasis. METHODS: This single-arm longitudinal interventional study enrolled five healthy adults who underwent a 72-hour water-only fast. Blood samples were collected at baseline (T0), imm…

Forensic DNA analysis has already influenced criminal justice, and serves as a powerful tool for both conviction and exoneration. Despite its scientific foundations and wide application, DNA evidence is vulnerable to interpretive errors, methodological limitations, and cognitive bias, as demonstrated by numerous wrongful convictions identified through the Innocence Project. Recent artificial inte…

AIM: To compare plasma protein and IgG N-glycosylation levels in pediatric patients undergoing acute appendicitis surgery and in those undergoing minor elective surgery. The secondary aim was to explore whether the plasma N-glycome profile may serve as a biomarker of systemic inflammatory burden in children. METHODS: This prospective study enrolled children aged 4-16 years undergoing minor electi…

AIM: To reconstruct the forensic identification process following the 1994 explosion at the Duboki Jarak military ammunition and explosive ordnance storage facility in Croatia and to evaluate the role of early PCR-based DNA typing in the identification of severely fragmented human remains under wartime conditions. METHODS: A retrospective archival analysis was conducted using original forensic, j…

). Results indicate over 95% retention of mixed pollutants. Visible light irradiation significantly enhances the M3 membrane's FRR to 91.6%, further demonstrating the Ti-MOF/CN composite membrane's robust long-term operational stability and self-cleaning capability for photocatalytic degradation of aqueous pollutants.

Immunotherapy has revolutionized cancer treatment, yet substantial inter-patient response heterogeneity limits therapeutic benefit to specific patient subsets. Here, we present PathTIGR, a pathway topology-informed graph representation learning framework that systematically integrates biological pathway network topology knowledge with genome variation information for immunotherapy response predic…