Coencapsulation of doxorubicin and curcumin in liposomes modified with folic acid for reversal of drug resistance in glioma

Introduction Multidrug resistance (MDR) critically limits doxorubicin (Dox) efficacy in glioma. To overcome this, we constructed a folic acid receptor (FAR)-targeted liposomal system for codelivering Dox and curcumin (Cur). Methods Dox/Cur-Lip@FA was prepared using the film hydration-sonication method. The physicochemical properties (size, zeta potential, encapsulation efficiency, and drug release) were characterized. The studies assessed P-gp modulation and cellular uptake in Dox-resistant C6 c