Frontiers in Oncology

Anastomosing hemangioma (AH) is a rare benign vascular neoplasm. It has been reported most commonly in the testes and genitourinary system [1-2], but it has also been described in the liver [3], gastrointestinal tract, ovary , and paraspinal region [4]. Although AH is well differentiated and has no malignant potential, it lacks specific imaging features and is therefore difficult to diagnose preo…

Tyrosine kinase inhibitors (TKIs) demonstrate clear therapeutic effects in patients with HER2−positive breast cancer complicated by brain metastases. However, the efficacy and safety of salvage stereotactic radiotherapy (SRT) for intracranial oligoprogression after TKI therapy remain unclear. This single-center retrospective cohort study aimed to evaluate the clinical value of SRT in this specifi…

Cervical cancer remains a major health concern with over 662,000 cases and 348,000 deaths worldwide yearly. Treatment of early stage disease is generally surgical resection with excellent 5-year survival rates. Locally advanced cervical cancer (LACC) is potentially curable but still has only an approximately 50% 5-year survival rate. LACC is currently treated with chemoradiotherapy (cisplatin). C…

Objective Various guidelines recommend offering germline genetic testing to all patients diagnosed with epithelial ovarian cancer, as it helps guide treatment decisions, identify cancer risks in other organs, and empowers patients to notify families for timely screening and risk-reducing surgery. Our study aimed to explore the awareness and uptake rate of germline genetic testing among Chinese wo…

Objective Prolonged air leak (PAL), defined as air leakage lasting more than 5 days, remains a prevalent complication following uniportal video-assisted thoracic surgery (uVATS) segmentectomy, contributing to extended hospitalization, elevated medical expenditures, and higher postoperative morbidity. This study was designed to develop and internally validate machine learning models for predicting…

Purpose To identify the key clinical and imaging clues on computed tomography (CT) and magnetic resonance imaging (MRI) that can suggest the diagnosis of hepatic AL amyloidosis, thereby improving diagnostic accuracy and timely recognition among peers. Methods We retrospectively analyzed the clinical, CT, and MRI findings of 10 patients with confirmed hepatic AL amyloidosis. Results The predominan…

Objective To systematically summarize study-level factors associated with postoperative hematoma after ultrasound-guided vacuum-assisted breast lesion excision(VAE) using a vacuum-assisted breast biopsy (VABB) system, and to organize the available evidence according to a novel T-P-B framework comprising tumor-related, position-related, and breast- or peri-procedural management-related factors. Me…

Ribosomes are central to cellular growth and proteome maintenance, and cancer cells frequently depend on increased ribosome biogenesis and altered translation to sustain proliferation, stress tolerance, and metabolic rewiring. Paradoxically, inherited “ribosomopathies” caused by germline defects in ribosomal proteins or ribosome biogenesis factors present with tissue hypoplasia and bone marrow fa…

Esophageal cancer is one of the most harmful upper gastrointestinal cancers, particularly in its advanced stages. Squamous cell carcinoma accounts for approximately 85% of all esophageal cancer cases among Chinese patients and is the main pathological type. Although first-line immunotherapy combined with chemotherapy has improved survival rates for stage IV esophageal squamous cell carcinoma (ESC…

Introduction Alpha-thalassemia/mental retardation syndrome X-linked (ATRX) mutation is an uncommon but biologically relevant molecular feature in glioblastoma (GBM), linked to tumor heterogeneity, DNA damage response pathways, and treatment-relevant biology. Noninvasive prediction of ATRX status remains challenging, and the incremental value of physiologic MRI beyond structural imaging is unclear…

Background Advanced colorectal cancer (CRC) has limited therapeutic options. Antibody-drug conjugates (ADCs) deliver cytotoxic agents selectively, minimizing systemic toxicity. This study outlines the current clinical trial landscape of ADCs in CRC to identify research gaps and future directions. Methods We queried the Trialtrove database (up to August 2025) for non-observational trials of ADCs i…

This article reports a case of a 72-year-old male with intrahepatic cholangiocarcinoma who developed acute symptoms—including chest tightness, muscle weakness, ophthalmoplegia, and dyspnea—3 days after receiving the second cycle of adebrelimab, following combination therapy with adebrelimab, apatinib, and tegafur. These complications proved fatal. Laboratory tests showed significant elevation of …

Background Upper tract urothelial carcinoma (UTUC) is a relatively rare but aggressive malignancy. Accurate preoperative assessment of tumor grade, invasiveness, and prognosis remains challenging using conventional imaging, cytology, and ureteroscopic biopsy alone. Radiomics and deep learning may provide noninvasive tools for improving risk stratification and clinical decision-making. Methods Thi…

Introduction Rosai–Dorfman–Destombes disease (RDD) is a rare non-Langerhans histiocytic disorder with occasional extranodal involvement. Orbital disease can mimic neoplastic or inflammatory conditions, leading to diagnostic and therapeutic challenges. Standardized management strategies remain undefined. Aim To describe the diagnostic complexity and therapeutic role of radiation therapy, including…

Objectives To explore hypermethylated gene markers in cervical scraped cells that may be associated with endometrial cancer and validate their diagnostic role in endometrial cancer. Methods In an exploratory cohort consisting of 40 paired endometrial tissue and cervical scraping samples, high-performance methylation-targeted genes associated with endometrial cancer were identified. In training an…

Objective This study aimed to investigate the levels of peripheral blood immune cells CD4 + , CD8 + , CD56 + , and regulatory T cells (Tregs) and the expression of tumor markers K-ras and Ki-67 in pathological tissues of patients with high-risk human papillomavirus (HR-HPV)-infected cervical lesions, and to explore their correlations with HPV-DNA viral load. Methods A total of 240 female patients…

Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype, lacking effective targeted therapies and exhibiting pronounced therapeutic resistance. Mitochondria have recently emerged as central regulators of TNBC pathogenesis, functioning beyond their traditional roles as cellular powerhouses. This article synthesizes current understanding of how mitochondrial metabo…

While implantable venous access ports (IVAPs) are a cornerstone of chemotherapy administration, they carry the risk of mechanical failures, including catheter fracture. We describe a rare instance in a 33-year-old patient with lung cancer and class III obesity (BMI 42.1 kg/m 2 ), who developed episodic pain around the port pocket. Diagnostic imaging revealed a structural failure of the catheter i…

Follicular dendritic cell sarcoma (FDCS) is a rare malignant neoplasm originating from follicular dendritic cells. We present a case of advanced FDCS arising in the mediastinum with multiple metastases. The diagnostic complexity, aggressive clinical course, and integrative therapeutic approach involving immunotherapy and targeted therapy offer clinically relevant insights for managing this rare a…

Introduction Multidrug resistance (MDR) critically limits doxorubicin (Dox) efficacy in glioma. To overcome this, we constructed a folic acid receptor (FAR)-targeted liposomal system for codelivering Dox and curcumin (Cur). Methods Dox/Cur-Lip@FA was prepared using the film hydration-sonication method. The physicochemical properties (size, zeta potential, encapsulation efficiency, and drug releas…