bioinformatics

Benchmarking the Honesty of Fine-Mapping Credible Sets Fine-mapping has a promise built into its output, and almost nobody checks whether the promise is kept. When you run SuSiE on a GWAS locus, it hands you a credible set : a small group of variants that, at a stated confidence level like 95%, should contain the true causal variant. That 95% is a claim about reality. Among all the loci where SuS…

Nature Communications, Published online: 21 June 2026; doi:10.1038/s41467-026-74716-3 Single-molecule fluorescence imaging struggles to distinguish signals from different molecular events when intensity profiles appear similar. Here, the authors introduce smDeepFLUOR, a deep learning framework that classifies spatiotemporal fluorescence signals with high accuracy across diverse molecular events, …

Nature Communications, Published online: 20 June 2026; doi:10.1038/s41467-026-74726-1 RNA polymerase II drives gene transcription through dynamic chromatin interactions. Here, the authors use single-molecule imaging to show that most binding events are short-lived, with rare productive events, and identify TAF1 as a regulator promoting pause release and elongation.

Scientific Data, Published online: 20 June 2026; doi:10.1038/s41597-026-07646-w A high-quality chromosome-level genome assembly of Ficus carica cultivar ‘Green Peel’

When researchers paste DNA sequences into online tools, they rarely consider where that data goes. Yet a single gene sequence could represent months of lab work, unpublished findings, or even patent-pending discoveries. This is why I believe browser-based bioinformatics tools should be built with privacy-by-design principles — processing everything client-side whenever possible. The Problem with …

Nature Chemistry, Published online: 19 June 2026; doi:10.1038/s41557-026-02185-8 Few nickel enzymes have been discovered to date, limiting understanding of nickel-catalysed chemistry in nature. Now, a unique family of nickel pincer mononucleotide-utilizing enzymes has been identified through bioinformatics and characterized through biochemical and structural studies, expanding the known repertoir…

Nature Communications, Published online: 19 June 2026; doi:10.1038/s41467-026-74587-8 King and colleagues use scTECH-seq to attain spatial mapping of single-cell gene expression and drug response in three-dimensional cultured cell spheroids. Spatial expression analysis provides insight into heterogeneous drug responses in 3D culture models.

Published on June 18, 2026 2:54 PM GMT Hi everyone, My name is Gian, the founder of HELGEN (biosecurity / biodefense), focusing on detecting biological threats in the environment. We have established partnerships with professorships in TUM and LMU (Munich, Germany), and looking for someone who could potentially join as member to apply for EXIST / other German and EU grants. I am looking for a co-…

Scientific Data, Published online: 18 June 2026; doi:10.1038/s41597-026-07220-4 High-Quality Genome Assembly of the White King Pigeon for Genetic Reference of Chinese Market Pigeon Breeds

Nature Communications, Published online: 18 June 2026; doi:10.1038/s41467-026-74059-z Predicting protein splitability is pivotal for engineering functional variants. Here the authors present SplitSeek-Pro, a deep learning model integrating sequence and 3D features to achieve accurate residue-resolution split site prediction for protein design.

BackgroundHost–microbiome research has expanded rapidly over the past two decades, generating extensive evidence linking microbial communities to immune regulation, metabolism, epithelial barrier integrity, and neuroendocrine signaling. Despite this progress, the organizational architecture through which exogenous biological signals become integrated into human physiological regulation remains co…

EMBL Grenoble Data Scientist for AI Alana Sousa talks about how she went from analysing star formation to improving a machine learning tool for crystal identification in structural biology.

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10667-5 The Pakistan Genome Resource compiles biobank data from 173,303 individuals with high familial relatedness, broadening the catalogue of human genetic variation and establishing a population-specific genomic reference for Pakistan.

Scientific Data, Published online: 17 June 2026; doi:10.1038/s41597-026-07638-w A chromosome-level reference genome assembly and annotation of Serrodes campana