internal-medicine

BackgroundChildren with solid tumors experience prolonged treatment, repeated hospital visits, and psychosocial stressors. This exploratory single-center cross-sectional study evaluated anxiety symptoms, depressive symptoms, and health-related quality of life in children with solid tumors and examined their associations with selected sociodemographic, clinical, school functioning, and social func…

Nature Communications, Published online: 22 June 2026; doi:10.1038/s41467-026-74698-2 A study in mice and humans reveals that a placental enzyme AOC1 and the molecule spermidine help time labor through regulating autophagy. Boosting spermidine prevented preterm birth, suggesting a potential therapy for human premature labor.

The event highlighted research aiming to enhance the detection of eye diseases using AI and maps of the retina, alongside emerging science addressing macular degeneration, glaucoma, myopia and more. The post USC Roski Eye Institute marks golden anniversary with forward-looking symposium appeared first on USC .

Insider indicates Ockenden inquiry has uncovered appalling behaviour including racism toward mothers The report of the inquiry into the biggest maternity scandal in NHS history will outline “horrendous” failings in the care provided to women in Nottingham, the Guardian can reveal. A catalogue of appalling behaviour over many years by staff at the city’s two hospitals – Queen’s Medical Centre and …

BackgroundBiktarvy, a second-generation integrase strand-transfer inhibitor, is approved for treating human immunodeficiency virus (HIV) in patients with no known resistance to its components. This study compared adverse events (AEs) associated with biktarvy based on data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database and real-world evidence fr…

BackgroundChronic Hepatitis B (CHB) is a major global health concern. This study aimed to evaluate whether myxovirus resistance 2 (MX2) and sterile alpha motif domain containing 4A (SAMD4A) mRNA levels in peripheral blood mononuclear cells (PBMCs) can predict early treatment responses to pegylated interferon-alpha (Peg-IFN-α) in hepatitis B e antigen (HBeAg)-positive CHB patients.MethodsThis pros…

BackgroundPlant-Derived Exosome-Like nanoparticles (PELNs) are vital bioactive vesicles from medicinal plants, containing protective flavonoids, polyphenols, alkaloids, terpenoids, saponins, polysaccharides, and microRNAs. These compounds play crucial roles in PELNs’ anti-inflammatory and other pharmacological effects. PELNs show promise as a treatment in animal experiments for ulcerative colitis…

BackgroundCardiovascular diseases remain an urgent global health concern addressed by multiple clinical guidelines. Atherothrombosis is characterised by thrombus formation following disruption of atherosclerotic plaque, leading to major adverse cardiovascular events, such as myocardial infarction and stroke. Platelet hyperactivity is a key driver of these outcomes, leading causes of morbidity and…

BackgroundThe co-administration of neuraxial drugs can enhance analgesic effects and reduce adverse events associated with epidural labor analgesia. This study aimed to explore the effects of epidural analgesia supplemented with lidocaine on maternal intrapartum fever.MethodsThe control group received epidural analgesia with 0.1% ropivacaine and fentanyl 2 μg/mL, while Group L received epidural a…

ObjectiveF. africana Lehm (Poaceae) is a perennial grass traditionally used in ethnomedicine for the treatment of gastrointestinal disorders and wound healing. Despite its traditional relevance, its phytochemical composition and pharmacological activities remain largely unexplored. This study aimed to comprehensively characterize the phytochemical and elemental profiles of Fingerhuthia africana a…

BackgroundLecanemab and donanemab are anti-amyloid-β (Aβ) monoclonal antibodies recently approved for the treatment of Alzheimer’s disease (AD). Although both agents have demonstrated therapeutic potential, their post-marketing adverse event reporting profiles remain insufficiently characterized and compared in spontaneous reporting systems. This study aimed to systematically compare adverse even…

BackgroundLigustilide (LIG), a natural phthalide compound mainly isolated from Angelica sinensis and Ligusticum chuanxiong, has attracted increasing attention because of its diverse pharmacological activities, including anti-inflammatory, antioxidant, anti-apoptotic, and neuroprotective effects. Emerging studies suggest that LIG may have therapeutic relevance in central nervous system (CNS) disor…

Ischemic stroke currently lacks evidence-based neuroprotective agents, primarily due to the challenge of timely intervention, which often occurs after the onset of irreversible neuronal damage. To address this, this study investigates the PARthanatos pathway, a form of regulated cell death triggered by DNA damage. Utilizing MNNG-induced cellular PARthanatos models, we screened a library of 2,939 …

BackgroundThis study aims to investigate the potential association between 13 disease-modifying immunosuppressive drugs used to treat multiple sclerosis and intervertebral disc herniation, thereby filling a gap in pharmacovigilance research in this field.Materials and methodsWe extracted adverse event reports from the FAERS database covering 2005 to 2025. Disproportionality analyses using four es…

Scientific Reports, Published online: 22 June 2026; doi:10.1038/s41598-026-58998-7 Prognostic analysis of epithelial ovarian cancer patients with normal CA125 level: a population-based comparative study

With aid funding falling by 70%, a change to HIV response is needed. The continent must treat health as a matter of sovereignty rather than charity The Bundibugyo Ebola outbreak now being fought across the region shows again what Africa already knows. When an emergency arrives, the continent cannot wait on distant supply chains or other people’s goodwill. It must make and move the things that kee…

As prime minister, he would have a unique chance to turn the world’s most bureaucratic health service into its most innovative one If Andy Burnham moves from Manchester to No 10, he will be the first prime minister to have been health secretary in the history of the NHS. What might that mean for the troubled service? His commitment to social care is well known. But when the Treasury tells him the…

A nationwide Icelandic study found that 6.9% of women aged 18-69 reported trauma-associated sleep disturbances in the past month. These symptoms were most common after sexual or physical violence, recent or repeated trauma, and were strongly linked to PTSD, anxiety, depression, and general sleep problems.

ObjectiveThis study aimed to reveal the profiles of the flourishing in undergoing maintenance hemodialysis (MHD) and to investigate influencing factors guided by the principles of Social Support Resource Theory.MethodsA total of 376 MHD patients were recruited between October and November 2022. The study used the PERMA Profiler of Chinese Version, Regulatory Emotional Self-Efficacy Scale, Perceiv…

MIRA, an autonomous AI agent tested in a sandboxed electronic health record, diagnosed 574 real emergency department cases with 88.9% accuracy and outperformed physicians in a matched 311-case comparison. The system ordered tests, generated medication plans, and made admission decisions in simulation, but the authors stress that prospective validation, governance, and physician oversight are stil…