The female reproductive tract (FRT), particularly the vagina, has traditionally been regarded as a sterile environment. However, it is now recognized that the vagina is a complex, dynamic ecosystem dominated by Lactobacillus species, which maintain internal homeostasis through acid production, competitive exclusion, and immune regulation. Microbial dysbiosis, characterized by a loss of Lactobacillus dominance, increased microbial diversity and overgrowth of pathogenic bacteria, triggers chronic