Nature Communications, Published online: 21 June 2026; doi:10.1038/s41467-026-74103-y Here authors use human iPSC-derived cerebral organoids to model the pathogenic m.3243 A > G mitochondrial mutation and reveal heteroplasmy-dependent, cell-type-specific vulnerability in human cortex neurons.
Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation
Rita Horvath