Nature Communications, Published online: 21 June 2026; doi:10.1038/s41467-026-74689-3 Detoxifying the immunogenic lipopolysaccharide (LPS) remains challenging. Here, the authors show that the Brassicaceae protein LORE binds LPS with high affinity and develop plant-derived nanovesicles displaying native LORE, combined with cerium-based nanozymes, to enable LPS hydrolysis.