neuroimaging

Nature Communications, Published online: 22 June 2026; doi:10.1038/s41467-026-74553-4 Aggarwal et al. develop OCaMP, an orange fluorescent calcium indicator optimised for imaging neural activity at wavelengths above 1000 nm, enabling improved deep tissue imaging and expanded compatibility with existing sensors.

Fathers show changes in some of the same brain areas as mothers, but the effect of parenthood on dads isn’t nearly as well studied

Simultaneous voltage imaging of soma and dendrites in layer 2/3 cortical neurons in live mice reveals rich dynamics of spike back-propagation, with amplitude shaped by spiking history, dendrite location and behavioral state.

If we can model a fly brain, and run that fly in a sim, we might do it with us. We live in the age of the brain, and relational machines, when we can do so much more than ever.

Every neural-network tutorial I tried threw equations at me before I ever saw what was actually happening. I wanted the reverse: watch the activations flow forward, watch the loss bars shrink, watch backprop push gradients right-to-left across the layers. So I built it. Here's a neural network that trains itself in front of you 👇 What you're actually seeing Forward pass — particles flow left → ri…

Rotating neuronal waves are built into brain anatomy and help coordinate far-flung regions, mouse imaging study suggests

Scientists have discovered two biologically distinct subtypes of autism using brain imaging. By studying both mice and humans, researchers linked reduced brain connectivity to synaptic function and increased connectivity to immune system activity.

Nature Neuroscience, Published online: 19 June 2026; doi:10.1038/s41593-026-02339-4 Simultaneous voltage imaging of soma and dendrites in layer 2/3 cortical neurons in live mice reveals rich dynamics of spike back-propagation, with amplitude shaped by spiking history, dendrite location and behavioral state.

Nature Neuroscience, Published online: 19 June 2026; doi:10.1038/s41593-026-02341-w Erucamide, a fatty acid amide reduced in degenerating retinas, activates myeloid cells via TMEM19 to release neurotrophic and angiogenic factors, rescuing photoreceptors and vasculature in mouse models of retinal degeneration.

Background and objectivesThe diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is an important imaging biomarker for assessing glymphatic system function. However, the cortical and white matter metrics associated with changes in the DTI-ALPS index have not been fully elucidated, and the relationship between these two types of metrics remains controversial.MethodsWe com…

Nature Communications, Published online: 19 June 2026; doi:10.1038/s41467-026-74576-x Little is known about how cerebellar population activity controls movements in ways distinct from individual neuron correlations. Here the authors show that Purkinje neuron population covariance uniquely influences motor coordination in mice.

High-altitude hypoxia imposes substantial challenges on cerebral oxygen delivery and brain functional regulation. Body mass index (BMI) may influence neurophysiological adaptation to such environments through metabolic and hemorheological pathways, yet its relationship with resting-state Electroencephalography (EEG) microstate dynamics remains unclear. This study examined whether blood viscosity …

Purpose The purpose of this study was to explore different brain network connectomic relationships subserving hand dexterity in patients with contrast-enhancing brain tumors during task and resting states. Method We measured hand dexterity, resting state functional connectivity, and task-based functional connectivity in 21 participants with newly diagnosed brain tumors. Hand dexterity was measure…

Nature, Published online: 18 June 2026; doi:10.1038/d41586-026-01967-x Researchers have tracked the electrical activity of individual brain cells during conversation in real time. Plus, the history of GPS and a cross-species transplant that could reveal clues about the origin of animals.

IntroductionArtificial cerebrospinal fluid (ACSF) is critical for maintaining neuronal function during surgical procedures, yet its specific neuroprotective advantages over commonly used irrigation solutions like physiological saline and phosphate-buffered saline (PBS) remain unclear.MethodsThis study compared the neuronal preservation properties of ACSF, saline, and PBS using HT22 mouse hippocam…

A newly identified molecule called OLE helped restore the brain’s immune cells to a more protective state in Alzheimer’s models. The treatment reduced toxic plaque buildup and improved memory, raising hopes for a new therapeutic approach.

IntroductionUltra-high field (UHF) 7 tesla (7T) MRI offers unique diagnostic opportunities for clinical neuroimaging. However, broader clinical implementation remains limited because the reduced radiofrequency (RF) wavelength at 7T causes RF transmit field (B1+) inhomogeneity, resulting in spatial variation in image signal and tissue contrast. These effects are particularly pronounced in the skul…

Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) has emerged as a promising noninvasive approach for probing cortical reactivity and network dynamics with millisecond temporal resolution, with growing relevance for mechanistic and clinical neuroscience. However, despite rapid expansion of the field, TMS-EEG findings remain difficult to interpret because of substant…