Multi-isotope calibration (MICal) was evaluated as an alternative quantitative strategy for multi-elemental determination by inductively coupled plasma mass spectrometry (ICP-MS) in complex agroalimentary matrices. Infrared-assisted digestion (IRAD) was employed as a rapid and acid-efficient sample preparation approach. Method performance was assessed using certified reference material and further demonstrated through the analysis of real samples, including compound feeds and animal-derived matr