Frontiers in Chemistry | New and Recent Articles

Spin crossover (SCO) is a well-established phenomenon by which transition-metal complexes can reversibly switch between low- and high-spin states, a phenomenon widely studied in materials chemistry. Recently, transition metal complexes that exhibit SCO have attracted increasing attention as catalysts in chemical reactions. Combining SCO with catalysis presents a promising strategy for creating sw…

IntroductionAddressing clinical challenges such as the toxicity of conventional chemotherapy and viral drug resistance, this study proposes and validates an innovative “host organelle-targeting” strategy. By disrupting the function of host lysosomes—an organelle commonly exploited by both tumors and viruses—we aim to develop novel therapeutic agents with dual antitumor and antiviral activity.Meth…

This study reports the green synthesis, characterization, and cytotoxic evaluation of zinc oxide (ZnO) nanoparticles. ZnO nanoparticles have been synthesized using 3 mL of waste peel extracted from Allium cepa (onion) and designated as O3. Comprehensive characterization has been performed using XRD, UV–Visible, FTIR, FESEM, HRTEM, DLS, and fluorescence spectroscopy. The UV–Visible spectrum exhibi…

IntroductionCharacterizing plant-derived compounds in complex botanical formulations remains challenging because of matrix complexity, structurally related analogues, and frequent isomerism. Xie-Bai-San decoction (XBSD), a traditional herbal formula composed of Cortex Mori, Cortex Lycii, and Radix et Rhizoma Glycyrrhizae, represents a complex botanical system requiring comprehensive phytochemical…

Nicotinamide mononucleotide (NMN) has anti-inflammatory, antioxidant, and mitochondrial function-enhancing properties, which demonstrate its significant neuroprotective potential. However, its high water solubility presents challenges with regard to blood-brain barrier (BBB) permeability, prompting extensive research interest. This study used a composite emulsification method combined with respon…

Accurate detection and localization of early-stage breast cancer represent the cornerstone for improving cancer cure rates and extending patient survival. However, selecting therapeutic regimens characterized by high efficacy and minimal side effects remains a formidable clinical challenge. Combining these two goals is now feasible with the innovation and progress of nanomaterials. Herein, we des…

Non-enzymatic photoelectrochemical (PEC) glucose sensing using ZnO nanorods (ZnO NRs) is typically constrained to UV excitation, as stoichiometric ZnO possesses a wide band gap. In this work, this UV-only limitation is addressed by deliberately exploiting intrinsic defect chemistry: zinc-vacancy (VZn) defects generated during low-temperature electrodeposition are engineered as the central design …

The recent synthesis of triple-pore covalent organic frameworks (TP-COFs), specifically TP-COF-DAB and TP-COF-BZ, represents a significant milestone in framework chemistry, as replicating such multi-pore architectures remains highly challenging. Despite their structural novelty, the mathematical perspective of their topology and associated properties is still limited. In this study, closed-form e…

Conventional nanozymes still suffer from limited catalytic efficiency and poor substrate selectivity, which impede their clinical translation. Recently, photo-responsive nanozymes have emerged as a promising platform for precision biomedicine by integrating photocatalytic processes with enzyme-mimetic catalysis, enabling spatiotemporally controlled enhancement of catalytic activity. In this revie…

Multi-isotope calibration (MICal) was evaluated as an alternative quantitative strategy for multi-elemental determination by inductively coupled plasma mass spectrometry (ICP-MS) in complex agroalimentary matrices. Infrared-assisted digestion (IRAD) was employed as a rapid and acid-efficient sample preparation approach. Method performance was assessed using certified reference material and furthe…

Quantitative Structure-Property Relationship (QSPR) modelling provides an efficient computational framework for predicting physicochemical properties of drug molecules when experimental data are limited. In this study, we investigate the predictive capability of degree-based topological indices (TIs) derived from SMILES (Simplified Molecular Input Line Entry System) representations for modelling …

Phosphorus recovery from industrial wastewater is an important route for alleviating phosphorus resource depletion and reducing eutrophication risk. Acidified oil wastewater generated during vegetable oil refining is characterized by strong acidity, high organic load, and high phosphorus content, making conventional treatment both costly and chemically intensive. Herein, an Fe-C micro-electrolysi…

Proteolysis Targeting Chimera (PROTAC) is an innovative drug discovery strategy that utilizes bifunctional small molecules to bring a target protein (POI) into proximity with an E3 ubiquitin ligase, thereby inducing ubiquitination of the pathogenic protein and its subsequent degradation by the proteasome. PROTACs exhibit a novel mechanism of action, catalytic efficiency, high selectivity, and bro…

A very recent experimental study [Proc. Natl. Acad. Sci. U.S.A. 123 (10) e2524790123] demonstrated that non-functionalized graphene (Gr) supported on silicon(111) catalyzed the decomposition of small sulfur-containing compounds under ultra-high vacuum. Accompanying density functional theory (DFT) calculations identify grain boundary defects (GBDs) and interfacial defects as the active sites. Func…

Carbon-based nanomaterials (CBNs), including carbon nanotubes (CNTs), fullerenes, and graphene (GN), have attracted significant attention due to their unique structural, electrical, mechanical, and biocompatible properties. Their high surface area, excellent biocompatibility, and tunable physicochemical characteristics enable a wide range of applications, particularly in biomedicine, electronics,…

Lithium-sulfur (Li-S) batteries are promising next-generation energy storage systems due to their high theoretical energy density. However, their practical implementation is hindered by the low conductivity of sulfur and the polysulfide shuttle effect. In this work, garlic-braid-derived biochar was investigated as a sustainable sulfur host for Li-S battery cathodes. Biochar obtained from garlic b…

BackgroundMajor depressive disorder (MDD) in adolescents remains a significant public health challenge. Treatment-resistant depression (TRD) affects a substantial proportion of cases and is associated with chronic symptoms, comorbidities, and elevated suicide risk. Standard treatments frequently show limited success, leading to off-label consideration of atypical antipsychotics as augmentation ag…

Fingerprints are still one of the most effective means of forensic detection but degradation during the recovery process leads to a loss of contrast between ridge and background, making them difficult to visualize. In this study spinel copper aluminate (CuAl2O4) nanoparticles were synthesized by a facile and cost effective sol-gel method and evaluated for latent fingerprints (LFPs) development on…